Call of Cthulhu: Dark Corners of the Earth is a survival horror video game developed by Headfirst Productions and published by Bethesda Softworks with 2K Games and Ubisoft for the PC and Xbox systems. The game was published first for the Xbox in 2005 and the PC version followed in 2006.

Call of Cthulhu: Dark Corners of the Earth combines an action-adventure game with a relatively realistic first-person shooter, as well as with elements of a stealth game. The game is based on the works of H. P. Lovecraft, author of "The Call of Cthulhu" and progenitor of the Cthulhu Mythos, and in particular the game is a reimagining of Lovecraft's 1936 novella The Shadow Over Innsmouth. Set mostly in the year 1922, the story follows Jack Walters, a mentally unstable private detective hired to investigate a missing person case in Innsmouth, a strange and mysterious town that has cut itself from the rest of the United States.

In development since 1999, the project was repeatedly delayed, going through several revisions and having some of its most ambitious and immersive features abandoned and the initially planned PlayStation 2 version canceled. Although well received by most critics, the final game was a commercial failure. At least two additional Cthulhu Mythos games were planned by Headfirst Productions, including a direct sequel titled Call of Cthulhu: Destiny's End, but they were never completed due to Headfirst's failure to find a new publisher and their subsequent bankruptcy.