New cancer 'vaccine' completely wipes out tumors in mice
- 6 years ago
STANFORD, CALIFORNIA — Stanford University researchers used immune stimulators to target cancerous tumors, and it worked surprisingly well.
T-cells that defend against cancer often end up overpowered by the disease, but scientists find they can be rejuvenated using CpG oligonucleotides and anti-OX40 antibodies, according to the Stanford University School of Medicine.
When a microgram of the the immune-stimulating agents were injected directly into mouse tumors, the growths disappeared in about 10 days.
CpG activates dendritic cells that help against tumor counterattacks, while anti-OX40 antibodies stimulate T-cells into attacking the cancer.
Once a tumor is destroyed, the cells move through the body to find and eliminate other similar growths.
The experiment eradicated lymphoma in 87 out of 90 mice, and also worked on breast, colon, and melanoma cancers.
The team is looking to start clinical trials to see if the treatment will be as successful in humans.
T-cells that defend against cancer often end up overpowered by the disease, but scientists find they can be rejuvenated using CpG oligonucleotides and anti-OX40 antibodies, according to the Stanford University School of Medicine.
When a microgram of the the immune-stimulating agents were injected directly into mouse tumors, the growths disappeared in about 10 days.
CpG activates dendritic cells that help against tumor counterattacks, while anti-OX40 antibodies stimulate T-cells into attacking the cancer.
Once a tumor is destroyed, the cells move through the body to find and eliminate other similar growths.
The experiment eradicated lymphoma in 87 out of 90 mice, and also worked on breast, colon, and melanoma cancers.
The team is looking to start clinical trials to see if the treatment will be as successful in humans.