The game is set in Raccoon City in September 1998, two months after the events of Resident Evil. Most of the citizens have been turned into mindless creatures, referred to by survivors as zombies, due to an outbreak of a viral bioweapon known as the T-Virus, manufactured by Umbrella Corporation. The game begins at a gas station outside of the city, where rookie police officer Leon S. Kennedy meets college student Claire Redfield, who is looking for her brother Chris Redfield.

After being separated following a car accident, Leon and Claire agree to meet up at the city's police department. The building is infested by zombies, and other monsters, including the "Tyrant", who is dispatched to hunt down and kill any survivors. The creatures and various obstacles prevent Leon and Claire from actually reuniting as they are forced to find a way to escape the city.
Here is the Claire's 2nd scenario...