Alien Syndrome review. Classic Game Room reviews ALIEN SYNDROME for Sega Master System from 1988 (or 1987 depending which copyright you believe, the arcade game was 1987.) The Sega Master System video review of Alien Syndrome shows gameplay in HD that highlights the look and feel of the SMS version compared to that of the original arcade machine. The Alien Syndrome port on the SMS 8-Bit Sega Master System is a valiant attempt to recreate the original and succeeds for the home console circa 1988, but doesn't have the controls and smooth gameplay of the original Alien Syndrome arcade classic from Sega. Alien Syndrome remains a worthy collectable video game for Sega Master System collections.