Classic Game Room educational film: HOW TO CLEAN GAME CARTRIDGES! This CGR special shows you how to clean videogame cartridges using a Q-tip (not the rapper) and isopropyl alchol. Collecting for N64, Atari 2600, Colecovision, NES, SNES, Genesis or any other cartridge based video game console? Then odds are you'll run into some dirty game carts that need a simple cleaning before they work. If you buy used video game cartirdges you'll frequently find some that don't work when you power up the game system. A simple cleaning will fix the videogame cartridge 99% of the time because the contacts become dirty over time. Sometimes they become flat our disgusting and filthy. Clean your game cartridges with rubbing alcohol and a cotton swab and never let grime in the way of your gaming again!